منابع مشابه
Thinking big with small molecules
Synthetic chemistry has enabled scientists to explore the frontiers of cell biology, limited only by the laws of chemical bonding and reactivity. As we investigate biological questions of increasing complexity, new chemical technologies can provide systems-level views of cellular function. Here we discuss some of the molecular probes that illustrate this shift from a "one compound, one gene" pa...
متن کاملSmall molecules for big tasks.
One of the most important achievements in the post-genome era is discovery of microRNAs (miRNAs), which widely exist from simple-genome organisms such as viruses and bacteria to complex-genome organisms such as plants and animals. miRNAs are single-stranded non-coding RNAs of 18– 25 nucleotides in length, which are generated from larger precursors that are transcribed from non-coding genes. As ...
متن کاملUlrike Eggert: Big things from small molecules
JCB • VOLUME 194 • NUMBER 3 • 2011 352 Y ou can learn a lot if you have the right tool to help your investigations along. But where those tools don’t exist, you may have to work on a different question. Ulrike Eggert isn’t about to let a little thing like the lack of a tool get in her way—she’ll just make her own. Since her postdoc in Tim Mitchison’s lab at Harvard (1), Eggert has used a combin...
متن کاملChemical genetics to chemical genomics: small molecules offer big insights.
Chemical genetics is the study of biological systems using small molecule ('chemical') intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system. This tutorial review has been written to introduce this emerging field...
متن کاملBig plans for small molecules: NIH launches chemical genomics initiative.
The National Institutes of Health, as part of its new " Roadmap for Medical Research, " is launching a major chemical genomics initiative. Directors of almost every institute within NIH gathered in late September to announce plans for the Roadmap, a special program to speed the transition of basic research to medical advances (see box p. 1741). Little attention was given to the chemical genomic...
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ژورنال
عنوان ژورنال: Journal of Inherited Metabolic Disease
سال: 2019
ISSN: 0141-8955,1573-2665
DOI: 10.1002/jimd.12127